Our data reveals that Gli inhibitors JQ1, an epigenetic modulator which indirectly inhibits transcription of Gli by epigenetically targeting BRD4 [24], and GANT61 that interferes with the binding of Gli to the transcription site of target genes [23], suppresses the PGE2-provoked Hh activity and exhibited comparable inhibitory effect on the proliferation of colorectal cancer cells. Here, GLI1 is linked to colorectal cancer.