Wang et al. demonstrated that mTOR/S6K1 pathway non-canonically stimulated Gli activity through S6K1-mediated Gli1 phosphorylation at Ser84, which releases Gli1 from its endogenous inhibitor, SuFu protein, in esophageal adenocarcinoma cells [42]. The gene discussed is RPS6KB1; the disease is esophageal adenocarcinoma.