TP53 and acute lymphoblastic leukemia: For example, KARPAS-45 and CCRF-CEM with hot spot TP53 mutations (Table S2) and very high levels of mutant p53 expression were only moderately sensitive to APR-246 and their half-maximal inhibitory concentration (IC50) values (Table S3) did not differ from those of other ALL lines with lower levels of p53 expression.