In line with recent neuropathologic studies of plasma p-tau181 and NfL biomarkers,11,22,39 both plasma p-tau181 and NfL demonstrated high accuracy for separating those with pathology-confirmed AD from healthy controls, but only p-tau181 demonstrated high accuracy in separating pathology-confirmed AD cases from non-AD dementia cases. The gene discussed is NEFL; the disease is Alzheimer disease.