For a representative 65-year old female non-APOE ε4-carrier, the risk of AD is non-significantly higher if she has short and long rLTL compared with medium rLTL, with short rLTL showing a more pronounced risk of AD, in accordance with the trends from the cause-specific hazard model (Fig. 2 and Supplementary Table 2). The gene discussed is APOE; the disease is Alzheimer disease.