Importantly, compared with WT pigs, serum gastrin 17 (G-17) levels in DMD-delE51 pigs were significantly downregulated at week 7 (Fig. 5C, ***P < 0.001), serum pepsinogen I (PGI) levels were upregulated at week 6 and reached the peak at week 8, but then sharply declined to a minimum by week 12 (Fig. 5D, ***P < 0.001). The gene discussed is GAST; the disease is Duchenne muscular dystrophy.