YTHDF3 can promote the translation and degradation of mRNA [31]. In this study, we find that YTHDF2 specifically interacts with Myh7 mRNA, an important cardiac hypertrophy marker, to induce Myh7 mRNA decoy in an m6a-dependent manner in cardiomyocytes, and hypertrophic stimulation further enhances the interaction of YTHDF2 and Myh7 mRNA. Here, YTHDF2 is linked to cardiac hypertrophy.