YTHDF2 and cardiac hypertrophy: As shown in Fig. 5A–C, consistent with the results of Fig. 3C, overexpression of YTHDF2 evidently suppressed ISO or PHE-induced myocardial hypertrophy, whereas abolishment of YTHDF2’s RNA binding ability partially reversed the effect of overexpression of YTHDF2, suggesting that YTHDF2-mediated RNA metabolism is involved in the progression of cardiac hypertrophy.