There is evidence that acupuncture can improve menstrual frequency and ovulation frequency, decrease the levels of several sex steroids (including testosterone, androsterone glucuronide, androstane-3α, and 17β-diol-3-glucuronide) in women with PCOS, and improve the LH/FSH ratio [27, 28, 33]. The gene discussed is BRD2; the disease is polycystic ovary syndrome.