In this study, NEAT1 (Fig. 1A), miR-381 (Fig. 1B) and IGF1 (Fig. 1C–E) expression in ovarian granulosa cells of patients with PCOS was measured by RT-qPCR and Western blot analysis, and the results revealed that IGF1 and NEAT1 expression was increased and miR-381 expression was decreased in the PCOS group versus the non-PCOS group (all P < 0.05). Here, IGF1 is linked to polycystic ovary syndrome.