Another study showed that macrophage-derived exosomal miR-501-3p can inhibit the expression of the tumor suppressor TGFBR3 and promote the development of pancreatic ductal adenocarcinoma, providing a new target for the molecular therapy of pancreatic ductal adenocarcinoma [44]. The gene discussed is TGFBR3; the disease is pancreatic ductal adenocarcinoma.