CD4 and inborn error of immunity: In the low-risk group, we found that there were a number of immune-related pathways in the enriched pathways and biofunctions via GO and KEGG, such as T cell receptor complex, immunoglobulin production, CD4-positive or CD8-positive alpha-beta T cell lineage commitment, primary immunodeficiency, intestinal immune network for IgA production and RIG I-like receptor signaling pathway, which might imply the activation of immune responses in the low-risk group.