In the present study, we confirmed a novel regulatory network involving genetic and epigenetic regulations on CDC25A expression, where a transcription factor ALX3 recruits KDM2B to the promoter region of CDC25A which enhances CDC25A transcription through demethylation of H3K4me3, therefore leading to cell cycle progression and proliferation of cervical cancer cells. The gene discussed is KDM2B; the disease is cervical cancer.