Post-surgery measurement of serum MMP-13 was performed in 12 patients, which showed a marked decrease of serum MMP-13 concentrations after the removal of cSCC (523.0 ± 231.4 pg/ml prior-surgery versus 296.4 ± 92.6 pg/ml post-surgery, p < 0.001). The gene discussed is MMP13; the disease is skin squamous cell carcinoma.