The enterococcal accessory colonization proteins (Ace in E. faecalis and Acm in E. faecium) are collagen and laminin adhesins thought to be involved in endocarditis, as both ace and acm deletion mutants are attenuated in experimental endocarditis in rats, and antibodies specific for the collagen-binding domain of Ace protect rats from endocarditis [39]. Here, ACE is linked to endocarditis.