The most effective combinations in Schwann cells were slightly different and included: ALK-IN-1/dasatinib, TAE226 (a dual FAK/IGF-1R inhibitor)/dasatinib, and dasatinib/simvastatin (an HMG-CoA reductase inhibitor) for schwannoma (Figs 2E, S3 and S4). This evidence concerns the gene PTK2 and schwannoma.