SYN1 and schwannoma: To identify novel chemotherapeutic agents for NF2-associated tumors, we screened the NCATS MIPE library 4.0 of 1,932 compounds in a high-throughput dose-response format [9] using the isogenic pairs of NF2-expressing HS11 and NF2-deficient HS01 Schwann cells and NF2-expressing Syn1 and NF2-null Syn5 arachnoidal cells, as well as Nf2-/- mouse MS02 schwannoma cells and human Ben-Men-1 meningioma cells (Syn6).