Next we selected 176 pairwise compound combinations based on DBSumNeg values, synergy selectivity for NF2-deficient cells, mechanisms of interest, and clinical interest and tested them in 10x10 dose-response matrix format with the same set of meningioma and schwannoma cell models using both a cell viability readout (CellTiterGlo at 72h) and an apoptosis readout (CaspaseGlo, 20h). This evidence concerns the gene NF2 and meningioma.