Potential anti-proliferative mechanisms involved in melanoma cell apoptosis caused by cannabinoids are caspase-dependent apoptotic pathway [26, 27, 62, 65], inhibition of AKT and dephosphorylation of retinoblastoma protein [64], ERK phosphorylation [26], lipid raft machinery [26, 27] and activation of autophagy [65] (Fig. 1). This evidence concerns the gene AKT1 and melanoma.