Tokunaga et al. found that for adenocarcinoma of the esophagogastric junction, carcinoembryonic antigen (CEA) and CA19-9 positivity rates were significantly higher (P = 0.002 and < 0.001, respectively) in patients with myometrial and deeper tumor invasion (P ≤ 0.0063 [= 0.05/8]). The gene discussed is CEACAM5; the disease is gastroesophageal junction adenocarcinoma.