Scarpa et al. reported that serum levels of CA19-9 and CEA were significantly higher in patients with unresectable esophageal adenocarcinoma compared to those with resectable esophageal adenocarcinoma (P = 0.001 and P = 0.003, respectively), indicating that these were significant biomarkers of highly advanced cancer [12]. This evidence concerns the gene CEACAM5 and cancer.