VEGFA and wet macular degeneration: On the other hand, due to the increasing loss of choroidal blood vessels, the hypoxia of choroidal capillaries becomes more serious [36], which would stimulate the choroidal capillary endothelial cells to produce more angiogenic substances like VEGF, and hence, the expression of antiangiogenic mediator PEDF decreases, promoting the generation of CNV in lesions at the RPE/retina interface, which is a hallmark sign in the development of wet AMD in humans.