TRIM 43, an E3 ubiquitin ligase, suppresses the reactivation of herpesvirus by targeting centrosomal protein PCNT for degradation, which subsequently leads to the loss of nuclear envelope integrity and alterations in viral chromatin, suggesting PCNT as a potential therapeutic target in the treatment of herpesvirus infection (Full et al., 2019). The gene discussed is PCNT; the disease is Herpesviridae infectious disease.