In CheckMate 227,16 first-line therapy with nivolumab plus ipilimumab in patients with PD-L1–expressing NSCLC resulted in a numerically higher response rate and median duration of response (36.4% and 23.2 months, respectively) than with nivolumab monotherapy (27.5% and 15.5 months, respectively). Here, CD274 is linked to non-small cell lung carcinoma.