A recent study illustrated that propofol led to less lung metastasis than inhalational anesthetic sevoflurane in both syngeneic murine 4T1 and xenograft human MDA‐MB‐231 breast cancer models, demonstrating the effects of different anesthetics on tumor metastasis.[9] Specifically, sevoflurane promoted the lung metastasis by modulating inflammatory cytokines and activating STAT3 pathway in the lungs.[9] However, the study did not compare the difference of standard‐dose anesthetic (e.g., propofol) versus a low dose of the same anesthetic or nonanesthesia (control condition) on tumor metastasis. Here, STAT3 is linked to neoplasm.