SRC and neoplasm: RNAi knockdown of Src (Figure 2p) repressed the adhesion ability of HCT116 cells and blocked the propofol‐promoted adhesion and extension (Figure 2q,r; Figure S11f,g, Supporting Information). These data suggest that propofol inhibits Src ubiquitination by acting on GABAAR, leading to accumulation of Src, which then promotes tumor cell adhesion and extension.