Future studies using genetically modified tumor cells and two‐photon microscopy to visualize the acute dynamic process of cell adhesion will allow us to further determine whether propofol can promote adhesion of CTCs to VECs via interactions of GABAAR, TRIM21, and Src in vivo, leading to penetration of the vascular endothelium to start the process of extravasation. Here, TRIM21 is linked to neoplasm.