UBE3A and autism: The ALDH1A family consists of key enzymes that oxidize retinal into RA, and XX Xu et al. (Xu et al., 2018) found that ASD patients with excessive UBE3A (an autism-related gene and molecule) may have congenital errors of retinol metabolism, as excessive UBE3A can inhibit ALDH1A activity and compromise the oxidation of retinal to RA.