CASP1 and neoplasm: Furthermore, it was also confirmed experimentally that DCs derived from the bone marrow of Casp1−/− or Nlrp3−/−mice, pulsed with dying tumor cells, failed to elicit CTL mediated antitumor effects, suggesting that ATP- P2RX7 induced NLRP3 mediated caspase-1 activated IL-1β production is crucial for the IFN-γ–producing T cells to produce antitumor effects [13].