CD8A and neoplasm: Apart from that, the ATP released from dying cells also activates P2RX7 receptors on DCs which stimulates the NLRP3 inflammasomes, a caspase-1 activation platform, which further stimulates the cleavage of pro–IL-1β and the release of IL-1β, which is most important for priming of IFN-γ–producing, tumor antigen–specific CD8+ T cells.