In conclusion, our research firstly suggested the contribution of CYP2R1 SNPs (rs6486205, rs10741657, and rs2060793) and haplotypes (Ars10741657Ars2060793 and Grs10741657Grs2060793) to the increased CHD predisposition among the Chinese Han population, and these variants could serve as potential biomarkers of CHD susceptibility. Here, CYP2R1 is linked to coronary artery disorder.