In contrast, low TRPV4 expression was observed in only six cancer types, namely, adrenocortical carcinoma (ACC), kidney renal papillary cell carcinoma (KIRP), liver hepatocellular carcinoma (LIHC), prostate adenocarcinoma (PRAD), skin cutaneous melanoma (SKCM), and thyroid carcinoma (THCA) (Figure 1A). The gene discussed is TRPV4; the disease is cancer.