According to our enrichment analysis of SHOX2, the BP of SHOX2 was mainly associated with positive regulation of cell migration, cell division, skeletal system development, and mitotic nuclear division, and the significant KEGG pathways included the PI3K−Akt signaling pathway, ECM−receptor interaction, protein digestion and absorption, and amebiasis. The gene discussed is SHOX2; the disease is amebiasis.