In colorectal cancer (Wang et al., 2014), breast cancer (Jang et al., 2011), and gastric cancer (Liu et al., 2015), STUB1 functioned as a tumor suppressor and impaired the malignancy of colorectal, breast, and gastric cancer cells by inactivating NF-κB signaling. This evidence concerns the gene NFKB1 and colorectal cancer.