MET and acute kidney injury: In addition, the PERK-ATF4-CHOP pathway mediates endoplasmic reticulum (ER) stress (Taniguchi and Yoshida, 2015), autophagy (Kaushal and Shah, 2016), the TGFβ receptor (Linkermann et al., 2014), the HGF receptor (c-Met) (Zhou et al., 2013), p53 signaling (Zhang et al., 2014), etc., and these functions are associated with the initiation and development of AKI.