Mutations in CRB1 and CRB2 are implicated in retinal dystrophies in humans and deletion of the Crb2 gene in the mouse retina was reported to perturb development of the photoreceptor layer defects (Den Hollander et al., 1999; Alves et al., 2013; Chen et al., 2019). Here, CRB2 is linked to inherited retinal dystrophy.