Cardiac SIRT1 expression is markedly decreased in diabetes, and our previous work showed that enhancing SIRT1 expression and deacetylase activity can restrict ROS release and upregulate downstream antioxidant proteins, such as superoxide dismutase (SOD), the transcription factor forkhead box O1, and heme oxygenase 1 (HO1) (Yu et al., 2014; Waldman et al., 2019; Ren et al., 2020). This evidence concerns the gene HMOX1 and diabetes mellitus.