Moreover, signal transducer and activator of transcription 3 (STAT3) phosphorylation, activated by IL-6 and IL-10 in chronic lymphocytic leukemia patients’ sera, induces suppressor of cytokine signaling 5 expression, which in turn inhibits STAT6 activation (an essential molecule for MoDC differentiation), preventing monocyte differentiation and maturation (Toniolo et al., 2016; Kitamura et al., 2017). Here, STAT3 is linked to B-cell chronic lymphocytic leukemia.