CD4 and neoplasm: In the context of the cDC2 ability to induce antitumor responses, cDC2s were found to efficiently prime CD4+ T cells in vaccinated mice and induce Th17-cell differentiation, and most noteworthy, they were able to repolarize tumor-associated macrophages (TAMs) from M2 pro-tumoral phenotype into M1 antitumor phenotype (Laoui et al., 2016).