DCM relates to inherited gene mutations involved in sarcomeric protein synthesis [e.g., titin (TTN), MYH7, lamin A/C proteins (LMNA), desmin (DES)] or genes encoding ion channels [e.g., sodium channel protein type 5 subunit α (SCN5A)] (Gerull et al., 2002; Hershberger and Morales, 2007; Herman et al., 2012; Mcnally et al., 2013; Schultheiss et al., 2019). The gene discussed is DES; the disease is familial dilated cardiomyopathy.