CYP3A4 and hepatocellular carcinoma: Doxorubicin IC50 was higher, and sorafenib terminated less HCC population for HepG2 and C3Asub28 cells in cirrhotic, 7 mg/ml, microenvironments in general compared to healthy, 4 mg/mL, stiffness reflecting the CYP3A4 expression in those microenvironments.