ACSL4 and neoplasm: In consideration of significant increase of AA-residue-enriched PLs (e.g., PC(16:0_20:4), PE(16:0_20:4), PE(16:0p_20:4), PE(18:0p_20:4), PI(16:0_20:4), etc.), and the level of AA, so-called FA (20:4) significantly decreased in LaC serum, we speculated that ACSL4 may be activated and thereby prompt PLs accumulation, which associated with a greater degree of carcinogenesis in LaC tumor cells characterized by very abundant mitochondria.