However, the recent discontinuation of a phase III trial evaluating a bispecific antibody targeting TGF-β and PD-L1 (bintrafusp alfa [M7824]; NCT03631706), as first-line treatment for advanced stage lung cancer patients with high PD-L1, shows there is still significant work to be done in order to effectively target these pathways in humans. Here, CD274 is linked to lung cancer.