Importantly, CPZ-induced membrane dislodgement of K-Ras4B(G12V) was associated with apoptosis of Rat-1 fibroblasts cell lines stably expressing GFP-K-Ras(G12V), and cell cycle arrest and suppressed wound healing in human pancreatic cancer PANC-1 cell lines expressing GFP-K-Ras(G12V) cells [114]. This evidence concerns the gene KRAS and familial pancreatic carcinoma.