AKT1 and Ewing sarcoma: Interestingly, suppression of clathrin-mediated endocytosis has been implicated in the antitumorigenic effect of CPZ in Ewing sarcoma (ES), a childhood cancer that occurs in bones or surrounding soft tissue, where CPZ was shown to disrupt clathrin-dependent internalization of the insulin-like growth factor 1 receptor (IGF1R), inhibiting AKT and MAPK phosphorylation and reducing ES cell proliferation [92].