To test the therapeutic effects on CRC metastasis, Tauriello et al. generated compound mutant mice carrying Lgr5-CreERT2 and four key CRC mutations: Apcfl/fl, KrasLSL-G12D, Tgfbr2fl/fl, and Trp53fl/fl (designated L, A, K, T, and P, respectively) and established organoids from tumors developed in the LAKTP mice (Tauriello et al., 2018). Here, LGR5 is linked to colorectal carcinoma.