LTBP4 and colorectal carcinoma: The five genes which methylated signature corresponded to after annotation, included SCTR, PIK3CD, FGF5, PLXNC1, and LTBP4. The hypermethylation of SCTR is a biomarker for precursor lesions in CRC detection (Chen J. et al., 2019; Li et al., 2020).