Li et al. (2019) confirmed that the overexpression of PLXNC1 could promote cell proliferation and migration. According to a previous study, LTBP4 acts as a local regulator of transforming growth factor-β expression during tissue deposition and signaling in CRC, and the increase in LTBP4 expression might cause CRC (Berg et al., 2010). This evidence concerns the gene LTBP4 and colorectal carcinoma.