Through the LASSO Cox regression analysis, the seven AGs (POLA1, CDK1, SOCS2, HDAC1, MAPT, RAE1, and EEF1E1; Table 2, Supplementary Figure 2) were used to establish a risk score to predict the OS of HCC patients in the TCGA training set (Supplementary Figure 3). This evidence concerns the gene SOCS2 and hepatocellular carcinoma.