MAP3K5 and obesity due to melanocortin 4 receptor deficiency: Previous studies also showed the potential role of Map3k5, Met, and Vegfa in obesity and metabolic dysregulation (Rudich et al., 2007; Bian et al., 2010; Lu et al., 2012; Elias et al., 2013; Sundaram et al., 2014a, b; Hattori et al., 2016; Haim et al., 2017).