This finding prompted us to check the distributions of other common CLL driver genes (Landau et al., 2015; Puente et al., 2015) (i.e., TP53, NOTCH1, SF3B1, MYD88, BIRC3, RPS15, FBXW7 BRAF, EGR2, NFKBIE, XPO1, POT1, ZMYM3, and MGA) in all subtypes (Table 2). This evidence concerns the gene XPO1 and B-cell chronic lymphocytic leukemia.