This finding prompted us to check the distributions of other common CLL driver genes (Landau et al., 2015; Puente et al., 2015) (i.e., TP53, NOTCH1, SF3B1, MYD88, BIRC3, RPS15, FBXW7 BRAF, EGR2, NFKBIE, XPO1, POT1, ZMYM3, and MGA) in all subtypes (Table 2). The gene discussed is NFKBIE; the disease is B-cell chronic lymphocytic leukemia.