PAQR7 and tuberculosis: demonstrated that the expression of five regulons, DosR, MprA, PhoP, Rv1404, and Rv3058c, is responsible for the antibiotic tolerance of Mtb; these five regulons controlled the expression of over 50% of the upregulated genes after treatment with different anti-TB drugs, and their (DosR, PhoP, and MprA) deletion reduced drug tolerance under stress conditions (36).