To further confirm that in the absence of endogenous galectin-1 a functional defect in the Foxp3+CD4+Treg cells is involved in the severe response to DSS-colitis observed in Lgals1−/− mice, we adoptively transferred CD25highCD127low/− Foxp3+CD4+Treg cells (WT/TRegs) into colitic Lgals1−/− mice. Here, FOXP3 is linked to colitis.