In subjects with type 1 diabetes, C-peptide-NPY elicits the highest interferon-γ response, C-peptide-IAPP2 the highest IL-10 and IL-17 responses were observed at a similar magnitude for C-peptide-IAPP1, C13-32, and C22-A5 (Supplementary Figure 5A). This evidence concerns the gene NPY and type 1 diabetes mellitus.