IL17A and colorectal cancer: In colorectal cancer, hepatocellular carcinoma, gastric and pancreatic cancer, Th17 cells polarization in TME was associated with an unfavorable prognosis whereas its presence in prostate, epithelial ovarian cancer or uterine cervical cancer was associated with a better clinical outcome (20–24). The pro-tumoral roles of Th17 cells may be attributed to IL-17 proangiogenic functions.