TNF and COVID-19: Moreover, the progression of systemic inflammation and cytokine storm (e.g. significantly increased IL-2, IL-7, IL-10, GSCF, IP10, MCP-1, MIP1A and TNF-α levels) can potentially lead to multi-organ dysfunction (observed in approximately 5% of COVID-19 patients) and viral sepsis increasing the risk of mortality (12, 13).