Nevertheless, the marked beneficial action of MR antagonism demonstrated in the treatment of cardiac failure, often in the absence of elevated aldosterone or sodium retention, strongly suggests that a similar therapeutic approach would be worth of investigation in the context of different pathophysiological situations, including cardiomyopathies associated with diabetes mellitus, Cushing syndrome, or reperfusion after ischemia. The gene discussed is NR3C2; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.