MAPT and Alzheimer disease: We confirmed by Western blotting that tau is hyperphosphorylated at the pathology-associated phosphorylation sites S202/T205 [epitope recognized by AT8 antibody (43)] and S262, which are localized within the first KIGS motif, in AD brains (n = 10) as compared to control brains (n = 10, Figure 1, Supplementary Figure 1).