The antihypertensive effect exerted by GLP-1 and GLP-1R agonists seems dependent, in part, on dopamine beta-hydroxylase+ (DBH+) neurons located in the NTS of brainstem, as liraglutide injection into the fourth ventricle attenuated the development of hypertension in SHR rats with concomitant induction of c-FOS expression in NTS DBH+ neurons, whereas the ablation of these NTS DBH+ neurons dampened the antihypertensive effects of liraglutide injection (Katsurada et al., 2019). The gene discussed is DBH; the disease is Hypertension.