TNIK and Cognitive impairment: We also found significant DNA methylation changes in genes outside of canonical pathways implicated in high-altitude acclimatization (i.e., HIF and RAS), including significant DNA methylation changes in genes associated with cognitive impairment [ASH1L (de Ligt et al., 2012; Crawley et al., 2016; Xi et al., 2020) and TNIK (Coba et al., 2012; Anazi et al., 2016)].