ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: For CML, there is some evidence on the influence of methylation during the progression of the CML phases, as it was shown that the ABL1 promoter is hypermethylated in early stages of CML, as well as a global hypermethylation in CML blast crisis occurs (Machova Polakova et al., 2013; Heller et al., 2016).