CNR1 and post-traumatic stress disorder: Nevertheless, CBD and its combination with STR increased the Cnr1 gene expression in PTSD-like mice (Figure 9C, Two-way ANOVA, CBD: F(1,39) = 18.716, p < 0.001; STR: F(1,39) = 0.583, p = 0.450; CBD x STR: F(1,39) = 9.955, p < 0.01).